Rhythm Pharmaceuticals, Inc. (RYTM): Ownership & Insider Activity

Hedge funds and institutional managers reporting a position in RYTM · Health Care. Based on the most recent 13F filing from each holder, sourced from SEC EDGAR.

Reported Holders
28
13F filers
Aggregate Value
$1.6B
Across holders
Last Price
$111.44
2026-08-24
Sector
Health Care
GICS
Quarterly fund activity14 increased12 reduced3 exited
Full exits: Hudson Bay Capital Management LP, BALYASNY ASSET MANAGEMENT LLC, Brevan Howard Capital Management LP
Institutional Holders of RYTM
28 holders
ManagerTypeSharesMarket Value% of Total% of PortfolioActionQoQ ChangeQuarter
BAKER BROS. ADVISORS LP
CIK 0001263508
Hedge Fund5.60M$622.3M39.6%3.1%Unchanged+$0Q2 2026
PRIMECAP MANAGEMENT CO/CA/
CIK 0000763212
Institutional Manager3.17M$351.8M22.4%0.2%Reduced$-27.6MQ2 2026
CITADEL ADVISORS LLC
CIK 0001423053
Hedge Fund1.26M$140.3M8.9%0.0%Reduced+$136.9MQ2 2026
Woodline Partners LP
CIK 0001784547
Hedge Fund759K$84.3M5.4%0.3%Unchanged+$0Q2 2026
Clearbridge Investments, LLC
CIK 0001348883
Hedge Fund696K$77.3M4.9%0.1%Added+$9.7MQ2 2026
Squarepoint Ops LLC
CIK 0001642575
Hedge Fund423K$47.0M3.0%0.1%Added+$17.8MQ2 2026
Point72 Asset Management, L.P.
CIK 0001603466
Hedge Fund414K$46.0M2.9%0.1%Reduced$-48.0MQ2 2026
ADAGE CAPITAL PARTNERS GP, L.L.C.
CIK 0001165408
Hedge Fund397K$44.1M2.8%0.1%Reduced$-36.5MQ2 2026
ORBIMED ADVISORS LLC
CIK 0001055951
Hedge Fund323K$35.9M2.3%0.7%Added+$977KQ2 2026
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
Hedge Fund317K$35.2M2.2%0.0%Reduced$-15.0MQ2 2026
BAKER BROS. ADVISORS LPUnchanged
Hedge Fund
$622.3M· 39.6% of total· 3.1% port· 5.60M sh· +$0 QoQ· Q2 2026
PRIMECAP MANAGEMENT CO/CA/Reduced
Institutional Manager
$351.8M· 22.4% of total· 0.2% port· 3.17M sh· $-27.6M QoQ· Q2 2026
CITADEL ADVISORS LLCReduced
Hedge Fund
$140.3M· 8.9% of total· 0.0% port· 1.26M sh· +$136.9M QoQ· Q2 2026
Woodline Partners LPUnchanged
Hedge Fund
$84.3M· 5.4% of total· 0.3% port· 759K sh· +$0 QoQ· Q2 2026
Clearbridge Investments, LLCAdded
Hedge Fund
$77.3M· 4.9% of total· 0.1% port· 696K sh· +$9.7M QoQ· Q2 2026
Squarepoint Ops LLCAdded
Hedge Fund
$47.0M· 3.0% of total· 0.1% port· 423K sh· +$17.8M QoQ· Q2 2026
Point72 Asset Management, L.P.Reduced
Hedge Fund
$46.0M· 2.9% of total· 0.1% port· 414K sh· $-48.0M QoQ· Q2 2026
ADAGE CAPITAL PARTNERS GP, L.L.C.Reduced
Hedge Fund
$44.1M· 2.8% of total· 0.1% port· 397K sh· $-36.5M QoQ· Q2 2026
ORBIMED ADVISORS LLCAdded
Hedge Fund
$35.9M· 2.3% of total· 0.7% port· 323K sh· +$977K QoQ· Q2 2026
MILLENNIUM MANAGEMENT LLCReduced
Hedge Fund
$35.2M· 2.2% of total· 0.0% port· 317K sh· $-15.0M QoQ· Q2 2026
Duquesne Family Office LLCAdded
Family Office
$22.6M· 1.4% of total· 0.4% port· 204K sh· QoQ· Q2 2026
Qube Research & Technologies LtdReduced
Hedge Fund
$14.9M· 1.0% of total· 0.0% port· 134K sh· $-15.9M QoQ· Q2 2026
AXIOM INVESTORS LLC /DEReduced
Hedge Fund
$9.6M· 0.6% of total· 0.1% port· 87K sh· $-541K QoQ· Q2 2026
RENAISSANCE TECHNOLOGIES LLCReduced
Hedge Fund
$7.6M· 0.5% of total· 0.0% port· 68K sh· $-21.1M QoQ· Q2 2026
ExodusPoint Capital Management, LPAdded
Hedge Fund
$6.8M· 0.4% of total· 0.0% port· 61K sh· QoQ· Q2 2026
AQR CAPITAL MANAGEMENT LLCReduced
Hedge Fund
$6.6M· 0.4% of total· 0.0% port· 59K sh· +$6.4M QoQ· Q2 2026
Man Group plcAdded
Hedge Fund
$5.6M· 0.4% of total· 0.0% port· 51K sh· +$4.7M QoQ· Q2 2026
SHAW D E & CO INCReduced
Hedge Fund
$3.3M· 0.2% of total· 0.0% port· 30K sh· $-155K QoQ· Q2 2026
Schonfeld Strategic Advisors LLCAdded
Hedge Fund
$3.2M· 0.2% of total· 0.0% port· 29K sh· QoQ· Q2 2026
TUDOR INVESTMENT CORP ET ALReduced
Hedge Fund
$1.5M· 0.1% of total· 0.0% port· 14K sh· $-640K QoQ· Q2 2026
MARSHALL WACE, LLPReduced
Hedge Fund
$908K· 0.1% of total· 0.0% port· 8K sh· $-161K QoQ· Q2 2026
Walleye Capital LLCAdded
Hedge Fund
$666K· 0.0% of total· 0.0% port· 6K sh· QoQ· Q2 2026
Rockefeller Capital Management L.P.Added
Hedge Fund
$660K· 0.0% of total· 0.0% port· 6K sh· $-689K QoQ· Q2 2026
Gotham Asset Management, LLCAdded
Hedge Fund
$612K· 0.0% of total· 0.0% port· 6K sh· +$74K QoQ· Q2 2026
Fulcrum Asset Management LLPAdded
Hedge Fund
$556K· 0.0% of total· 0.1% port· 5K sh· QoQ· Q2 2026
TWO SIGMA INVESTMENTS, LPAdded
Hedge Fund
$511K· 0.0% of total· 0.0% port· 5K sh· +$33K QoQ· Q2 2026
Magnetar Financial LLCAdded
Hedge Fund
$434K· 0.0% of total· 0.0% port· 4K sh· QoQ· Q2 2026
CAPSTONE INVESTMENT ADVISORS, LLCAdded
Hedge Fund
$334K· 0.0% of total· 0.0% port· 3K sh· QoQ· Q2 2026
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