Stock Ownership/UPB

UPSTREAM BIO INC (UPB): Ownership & Insider Activity

Hedge funds and institutional managers reporting a position in UPB · Health Care. Based on the most recent 13F filing from each holder, sourced from SEC EDGAR.

Reported Holders
17
13F filers
Aggregate Value
$85.8M
Across holders
Last Price
$6.61
2026-08-24
Sector
Health Care
GICS
Quarterly fund activity14 increased0 reduced2 exited
Full exits: MARSHALL WACE, LLP, TUDOR INVESTMENT CORP ET AL
Institutional Holders of UPB
↗
17 holders
Manager⇅Type⇅Shares⇅Market Value▼% of Total⇅% of Portfolio⇅Action⇅QoQ Change⇅Quarter⇅
ORBIMED ADVISORS LLC
CIK 0001055951
Hedge Fund5.69M$39.4M45.9%0.7%Unchanged+$0Q2 2026
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
Hedge Fund1.14M$7.9M9.2%0.0%Added+$1.4MQ2 2026
SHAW D E & CO INC
CIK 0001009207
Hedge Fund1.04M$7.2M8.4%0.0%Added+$4.2MQ2 2026
Qube Research & Technologies Ltd
CIK 0001729829
Hedge Fund979K$6.8M7.9%0.0%Added+$2.5MQ2 2026
Woodline Partners LP
CIK 0001784547
Hedge Fund831K$5.8M6.7%0.0%Unchanged+$0Q2 2026
AQR CAPITAL MANAGEMENT LLC
CIK 0001167557
Hedge Fund545K$3.8M4.4%0.0%Added+$845KQ2 2026
Walleye Capital LLC
CIK 0001758720
Hedge Fund498K$3.4M4.0%0.0%Added—Q2 2026
Point72 Asset Management, L.P.
CIK 0001603466
Hedge Fund453K$3.1M3.7%0.0%Added+$3.1MQ2 2026
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
CIK 0001164508
Hedge Fund358K$2.5M2.9%0.0%Added+$1.2MQ2 2026
Squarepoint Ops LLC
CIK 0001642575
Hedge Fund291K$2.0M2.3%0.0%Added+$1.7MQ2 2026
ORBIMED ADVISORS LLCUnchanged
Hedge Fund
$39.4M· 45.9% of total· 0.7% port· 5.69M sh· +$0 QoQ· Q2 2026
MILLENNIUM MANAGEMENT LLCAdded
Hedge Fund
$7.9M· 9.2% of total· 0.0% port· 1.14M sh· +$1.4M QoQ· Q2 2026
SHAW D E & CO INCAdded
Hedge Fund
$7.2M· 8.4% of total· 0.0% port· 1.04M sh· +$4.2M QoQ· Q2 2026
Qube Research & Technologies LtdAdded
Hedge Fund
$6.8M· 7.9% of total· 0.0% port· 979K sh· +$2.5M QoQ· Q2 2026
Woodline Partners LPUnchanged
Hedge Fund
$5.8M· 6.7% of total· 0.0% port· 831K sh· +$0 QoQ· Q2 2026
AQR CAPITAL MANAGEMENT LLCAdded
Hedge Fund
$3.8M· 4.4% of total· 0.0% port· 545K sh· +$845K QoQ· Q2 2026
Walleye Capital LLCAdded
Hedge Fund
$3.4M· 4.0% of total· 0.0% port· 498K sh· — QoQ· Q2 2026
Point72 Asset Management, L.P.Added
Hedge Fund
$3.1M· 3.7% of total· 0.0% port· 453K sh· +$3.1M QoQ· Q2 2026
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPAdded
Hedge Fund
$2.5M· 2.9% of total· 0.0% port· 358K sh· +$1.2M QoQ· Q2 2026
Squarepoint Ops LLCAdded
Hedge Fund
$2.0M· 2.3% of total· 0.0% port· 291K sh· +$1.7M QoQ· Q2 2026
Schonfeld Strategic Advisors LLCAdded
Hedge Fund
$1.6M· 1.8% of total· 0.0% port· 226K sh· +$446K QoQ· Q2 2026
RENAISSANCE TECHNOLOGIES LLCAdded
Hedge Fund
$909K· 1.1% of total· 0.0% port· 131K sh· +$479K QoQ· Q2 2026
Man Group plcAdded
Hedge Fund
$511K· 0.6% of total· 0.0% port· 74K sh· +$364K QoQ· Q2 2026
Brevan Howard Capital Management LPAdded
Hedge Fund
$349K· 0.4% of total· 0.0% port· 50K sh· — QoQ· Q2 2026
TWO SIGMA INVESTMENTS, LPAdded
Hedge Fund
$293K· 0.3% of total· 0.0% port· 42K sh· — QoQ· Q2 2026
ExodusPoint Capital Management, LPAdded
Hedge Fund
$284K· 0.3% of total· 0.0% port· 41K sh· — QoQ· Q2 2026
Rockefeller Capital Management L.P.Unchanged
Hedge Fund
$5K· 0.0% of total· 0.0% port· 738 sh· +$0 QoQ· Q2 2026
1–10 of 17
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