IONIS PHARMACEUTICALS INC (IONS): Ownership & Insider Activity
Hedge funds and institutional managers reporting a position in IONS · Health Care. Based on the most recent 13F filing from each holder, sourced from SEC EDGAR.
Reported Holders
25
13F filers
Aggregate Value
$1.2B
Across holders
Last Price
$62.04
2026-08-24
Sector
Health Care
GICS
Quarterly fund activity10 increased14 reduced3 exited
| Manager⇅ | Type⇅ | Shares⇅ | Market Value▼ | % of Total⇅ | % of Portfolio⇅ | Action⇅ | QoQ Change⇅ | Quarter⇅ |
|---|---|---|---|---|---|---|---|---|
| TWO SIGMA INVESTMENTS, LP CIK 0001179392 | Hedge Fund | 6.25M | $495.7M | 43.0% | 0.4% | Added | +$31.3M | Q2 2026 |
| TWEEDY BROWNE CO LLC// CIK 0000732905 | Institutional Manager | 2.28M | $180.8M | 15.7% | 13.7% | Added | +$372K | Q2 2026 |
| BAKER BROS. ADVISORS LP CIK 0001263508 | Hedge Fund | 2.05M | $162.4M | 14.1% | 0.8% | Unchanged | +$0 | Q2 2026 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC CIK 0001556921 | Hedge Fund | 655K | $52.0M | 4.5% | 0.2% | Reduced | $-1.4M | Q2 2026 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP CIK 0001164508 | Hedge Fund | 632K | $50.1M | 4.3% | 0.0% | Reduced | $-8.4M | Q2 2026 |
| RENAISSANCE TECHNOLOGIES LLC CIK 0001037389 | Hedge Fund | 559K | $44.4M | 3.8% | 0.1% | Added | +$20.1M | Q2 2026 |
| Qube Research & Technologies Ltd CIK 0001729829 | Hedge Fund | 334K | $26.5M | 2.3% | 0.0% | Added | +$23.1M | Q2 2026 |
| SHAW D E & CO INC CIK 0001009207 | Hedge Fund | 297K | $23.6M | 2.0% | 0.0% | Reduced | $-23.4M | Q2 2026 |
| MILLENNIUM MANAGEMENT LLC CIK 0001273087 | Hedge Fund | 289K | $22.9M | 2.0% | 0.0% | Reduced | $-60.5M | Q2 2026 |
| CITADEL ADVISORS LLC CIK 0001423053 | Hedge Fund | 236K | $18.7M | 1.6% | 0.0% | Reduced | $-39.2M | Q2 2026 |
Added
Hedge Fund
$495.7M· 43.0% of total· 0.4% port· 6.25M sh· +$31.3M QoQ· Q2 2026
Added
Institutional Manager
$180.8M· 15.7% of total· 13.7% port· 2.28M sh· +$372K QoQ· Q2 2026
Unchanged
Hedge Fund
$162.4M· 14.1% of total· 0.8% port· 2.05M sh· +$0 QoQ· Q2 2026
Reduced
Hedge Fund
$52.0M· 4.5% of total· 0.2% port· 655K sh· $-1.4M QoQ· Q2 2026
Reduced
Hedge Fund
$50.1M· 4.3% of total· 0.0% port· 632K sh· $-8.4M QoQ· Q2 2026
Added
Hedge Fund
$44.4M· 3.8% of total· 0.1% port· 559K sh· +$20.1M QoQ· Q2 2026
Added
Hedge Fund
$26.5M· 2.3% of total· 0.0% port· 334K sh· +$23.1M QoQ· Q2 2026
Reduced
Hedge Fund
$23.6M· 2.0% of total· 0.0% port· 297K sh· $-23.4M QoQ· Q2 2026
Reduced
Hedge Fund
$22.9M· 2.0% of total· 0.0% port· 289K sh· $-60.5M QoQ· Q2 2026
Reduced
Hedge Fund
$18.7M· 1.6% of total· 0.0% port· 236K sh· $-39.2M QoQ· Q2 2026
Added
Hedge Fund
$11.9M· 1.0% of total· 0.0% port· 150K sh· +$7.9M QoQ· Q2 2026
Reduced
Hedge Fund
$11.5M· 1.0% of total· 0.0% port· 145K sh· $-11.9M QoQ· Q2 2026
Reduced
Institutional Manager
$10.9M· 0.9% of total· 0.0% port· 137K sh· $-346K QoQ· Q2 2026
Added
Hedge Fund
$9.6M· 0.8% of total· 0.0% port· 121K sh· +$1.8M QoQ· Q2 2026
Reduced
Hedge Fund
$8.7M· 0.8% of total· 0.0% port· 109K sh· $-46.5M QoQ· Q2 2026
Added
Hedge Fund
$7.7M· 0.7% of total· 1.2% port· 97K sh· +$4.4M QoQ· Q2 2026
Added
Hedge Fund
$6.3M· 0.5% of total· 0.0% port· 79K sh· +$4.0M QoQ· Q2 2026
Added
Hedge Fund
$2.8M· 0.2% of total· 0.0% port· 36K sh· — QoQ· Q2 2026
Added
Hedge Fund
$2.1M· 0.2% of total· 0.0% port· 26K sh· — QoQ· Q2 2026
Reduced
Hedge Fund
$1.7M· 0.2% of total· 0.0% port· 22K sh· +$1.7M QoQ· Q2 2026
Reduced
Hedge Fund
$980K· 0.1% of total· 0.0% port· 12K sh· +$696K QoQ· Q2 2026
Reduced
Hedge Fund
$674K· 0.1% of total· 0.0% port· 9K sh· $-4.9M QoQ· Q2 2026
Reduced
Hedge Fund
$304K· 0.0% of total· 0.0% port· 4K sh· $-483K QoQ· Q2 2026
Reduced
Hedge Fund
$176K· 0.0% of total· 0.0% port· 2K sh· $-14K QoQ· Q2 2026
Reduced
Hedge Fund
$159· 0.0% of total· 0.0% port· 2 sh· $-119K QoQ· Q2 2026
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