Praxis Precision Medicines, Inc. (PRAX): Ownership & Insider Activity

Hedge funds and institutional managers reporting a position in PRAX · Health Care. Based on the most recent 13F filing from each holder, sourced from SEC EDGAR.

Reported Holders
22
13F filers
Aggregate Value
$1.3B
Across holders
Last Price
$368.03
2026-08-24
Sector
Health Care
GICS
Quarterly fund activity16 increased3 reduced2 exited
Full exits: Hudson Bay Capital Management LP, Tetragon Partners GP Ltd
Institutional Holders of PRAX
22 holders
ManagerTypeSharesMarket Value% of Total% of PortfolioActionQoQ ChangeQuarter
BAKER BROS. ADVISORS LP
CIK 0001263508
Hedge Fund1.75M$587.0M46.9%2.9%Unchanged+$0Q2 2026
ADAGE CAPITAL PARTNERS GP, L.L.C.
CIK 0001165408
Hedge Fund1.02M$340.0M27.2%0.5%Added+$66.9MQ2 2026
ORBIMED ADVISORS LLC
CIK 0001055951
Hedge Fund230K$77.0M6.2%1.4%Added+$19.3MQ2 2026
Woodline Partners LP
CIK 0001784547
Hedge Fund200K$67.0M5.4%0.2%Unchanged+$0Q2 2026
Qube Research & Technologies Ltd
CIK 0001729829
Hedge Fund152K$51.0M4.1%0.0%Added+$8.1MQ2 2026
MARSHALL WACE, LLP
CIK 0001318757
Hedge Fund137K$45.9M3.7%0.0%Added+$45.8MQ2 2026
AQR CAPITAL MANAGEMENT LLC
CIK 0001167557
Hedge Fund58K$19.6M1.6%0.0%Reduced+$19.5MQ2 2026
ArrowMark Colorado Holdings LLC
CIK 0001483859
Hedge Fund46K$15.4M1.2%0.6%Reduced$-24.0MQ2 2026
Squarepoint Ops LLC
CIK 0001642575
Hedge Fund43K$14.2M1.1%0.0%Added+$13.6MQ2 2026
Clearbridge Investments, LLC
CIK 0001348883
Hedge Fund28K$9.4M0.7%0.0%AddedQ2 2026
BAKER BROS. ADVISORS LPUnchanged
Hedge Fund
$587.0M· 46.9% of total· 2.9% port· 1.75M sh· +$0 QoQ· Q2 2026
ADAGE CAPITAL PARTNERS GP, L.L.C.Added
Hedge Fund
$340.0M· 27.2% of total· 0.5% port· 1.02M sh· +$66.9M QoQ· Q2 2026
ORBIMED ADVISORS LLCAdded
Hedge Fund
$77.0M· 6.2% of total· 1.4% port· 230K sh· +$19.3M QoQ· Q2 2026
Woodline Partners LPUnchanged
Hedge Fund
$67.0M· 5.4% of total· 0.2% port· 200K sh· +$0 QoQ· Q2 2026
Qube Research & Technologies LtdAdded
Hedge Fund
$51.0M· 4.1% of total· 0.0% port· 152K sh· +$8.1M QoQ· Q2 2026
MARSHALL WACE, LLPAdded
Hedge Fund
$45.9M· 3.7% of total· 0.0% port· 137K sh· +$45.8M QoQ· Q2 2026
AQR CAPITAL MANAGEMENT LLCReduced
Hedge Fund
$19.6M· 1.6% of total· 0.0% port· 58K sh· +$19.5M QoQ· Q2 2026
ArrowMark Colorado Holdings LLCReduced
Hedge Fund
$15.4M· 1.2% of total· 0.6% port· 46K sh· $-24.0M QoQ· Q2 2026
Squarepoint Ops LLCAdded
Hedge Fund
$14.2M· 1.1% of total· 0.0% port· 43K sh· +$13.6M QoQ· Q2 2026
Clearbridge Investments, LLCAdded
Hedge Fund
$9.4M· 0.7% of total· 0.0% port· 28K sh· QoQ· Q2 2026
Man Group plcAdded
Hedge Fund
$7.1M· 0.6% of total· 0.0% port· 21K sh· +$6.0M QoQ· Q2 2026
TWO SIGMA INVESTMENTS, LPAdded
Hedge Fund
$6.3M· 0.5% of total· 0.0% port· 19K sh· +$388K QoQ· Q2 2026
Schonfeld Strategic Advisors LLCAdded
Hedge Fund
$3.5M· 0.3% of total· 0.0% port· 10K sh· QoQ· Q2 2026
CITADEL ADVISORS LLCAdded
Hedge Fund
$2.5M· 0.2% of total· 0.0% port· 7K sh· $-9.5M QoQ· Q2 2026
SHAW D E & CO INCAdded
Hedge Fund
$1.7M· 0.1% of total· 0.0% port· 5K sh· $-1.6M QoQ· Q2 2026
TUDOR INVESTMENT CORP ET ALAdded
Hedge Fund
$731K· 0.1% of total· 0.0% port· 2K sh· +$229K QoQ· Q2 2026
Magnetar Financial LLCAdded
Hedge Fund
$640K· 0.1% of total· 0.0% port· 2K sh· QoQ· Q2 2026
BALYASNY ASSET MANAGEMENT LLCAdded
Hedge Fund
$629K· 0.1% of total· 0.0% port· 2K sh· QoQ· Q2 2026
Brevan Howard Capital Management LPAdded
Hedge Fund
$495K· 0.0% of total· 0.0% port· 1K sh· +$169K QoQ· Q2 2026
JUPITER ASSET MANAGEMENT LTDAdded
Hedge Fund
$352K· 0.0% of total· 0.0% port· 1K sh· QoQ· Q2 2026
MILLENNIUM MANAGEMENT LLCReduced
Hedge Fund
$333K· 0.0% of total· 0.0% port· 995 sh· $-949K QoQ· Q2 2026
Rockefeller Capital Management L.P.Unchanged
Hedge Fund
$105K· 0.0% of total· 0.0% port· 315 sh· +$103K QoQ· Q2 2026
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