Stock Ownership/SYRE

SPYRE THERAPEUTICS INC (SYRE): Ownership & Insider Activity

Hedge funds and institutional managers reporting a position in SYRE · Health Care. Based on the most recent 13F filing from each holder, sourced from SEC EDGAR.

Reported Holders
20
13F filers
Aggregate Value
$447.9M
Across holders
Last Price
$106.65
2026-08-24
Sector
Health Care
GICS
Quarterly fund activity15 increased5 reduced2 exited
Full exits: BAKER BROS. ADVISORS LP, CAPSTONE INVESTMENT ADVISORS, LLC
Institutional Holders of SYRE
↗
20 holders
Manager⇅Type⇅Shares⇅Market Value▼% of Total⇅% of Portfolio⇅Action⇅QoQ Change⇅Quarter⇅
ADAGE CAPITAL PARTNERS GP, L.L.C.
CIK 0001165408
Hedge Fund1.72M$152.9M34.1%0.2%Added—Q2 2026
Holocene Advisors, LP
CIK 0001700574
Hedge Fund1.02M$90.1M20.1%0.2%Added—Q2 2026
MARSHALL WACE, LLP
CIK 0001318757
Hedge Fund992K$88.0M19.7%0.1%Added+$51.2MQ2 2026
Woodline Partners LP
CIK 0001784547
Hedge Fund306K$27.2M6.1%0.1%Added+$3.6MQ2 2026
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
Hedge Fund197K$17.5M3.9%0.0%Added+$4.4MQ2 2026
ORBIMED ADVISORS LLC
CIK 0001055951
Hedge Fund186K$16.5M3.7%0.3%Added—Q2 2026
BALYASNY ASSET MANAGEMENT LLC
CIK 0001218710
Hedge Fund147K$13.1M2.9%0.0%Added+$8.1MQ2 2026
Squarepoint Ops LLC
CIK 0001642575
Hedge Fund140K$12.4M2.8%0.0%Added—Q2 2026
CITADEL ADVISORS LLC
CIK 0001423053
Hedge Fund103K$9.2M2.0%0.0%Reduced+$6.4MQ2 2026
Hudson Bay Capital Management LP
CIK 0001393825
Hedge Fund58K$5.2M1.2%0.0%Added—Q2 2026
ADAGE CAPITAL PARTNERS GP, L.L.C.Added
Hedge Fund
$152.9M· 34.1% of total· 0.2% port· 1.72M sh· — QoQ· Q2 2026
Holocene Advisors, LPAdded
Hedge Fund
$90.1M· 20.1% of total· 0.2% port· 1.02M sh· — QoQ· Q2 2026
MARSHALL WACE, LLPAdded
Hedge Fund
$88.0M· 19.7% of total· 0.1% port· 992K sh· +$51.2M QoQ· Q2 2026
Woodline Partners LPAdded
Hedge Fund
$27.2M· 6.1% of total· 0.1% port· 306K sh· +$3.6M QoQ· Q2 2026
MILLENNIUM MANAGEMENT LLCAdded
Hedge Fund
$17.5M· 3.9% of total· 0.0% port· 197K sh· +$4.4M QoQ· Q2 2026
ORBIMED ADVISORS LLCAdded
Hedge Fund
$16.5M· 3.7% of total· 0.3% port· 186K sh· — QoQ· Q2 2026
BALYASNY ASSET MANAGEMENT LLCAdded
Hedge Fund
$13.1M· 2.9% of total· 0.0% port· 147K sh· +$8.1M QoQ· Q2 2026
Squarepoint Ops LLCAdded
Hedge Fund
$12.4M· 2.8% of total· 0.0% port· 140K sh· — QoQ· Q2 2026
CITADEL ADVISORS LLCReduced
Hedge Fund
$9.2M· 2.0% of total· 0.0% port· 103K sh· +$6.4M QoQ· Q2 2026
Hudson Bay Capital Management LPAdded
Hedge Fund
$5.2M· 1.2% of total· 0.0% port· 58K sh· — QoQ· Q2 2026
Rockefeller Capital Management L.P.Reduced
Hedge Fund
$4.2M· 0.9% of total· 0.0% port· 47K sh· $-12.6M QoQ· Q2 2026
FRED ALGER MANAGEMENT, LLCReduced
Hedge Fund
$2.6M· 0.6% of total· 0.0% port· 29K sh· $-2.7M QoQ· Q2 2026
SHAW D E & CO INCAdded
Hedge Fund
$2.3M· 0.5% of total· 0.0% port· 26K sh· — QoQ· Q2 2026
AQR CAPITAL MANAGEMENT LLCAdded
Hedge Fund
$2.0M· 0.5% of total· 0.0% port· 23K sh· +$2.0M QoQ· Q2 2026
Schonfeld Strategic Advisors LLCAdded
Hedge Fund
$1.7M· 0.4% of total· 0.0% port· 19K sh· — QoQ· Q2 2026
TWO SIGMA INVESTMENTS, LPAdded
Hedge Fund
$1.1M· 0.3% of total· 0.0% port· 13K sh· — QoQ· Q2 2026
Brevan Howard Capital Management LPAdded
Hedge Fund
$736K· 0.2% of total· 0.0% port· 8K sh· — QoQ· Q2 2026
Man Group plcReduced
Hedge Fund
$685K· 0.2% of total· 0.0% port· 8K sh· $-163K QoQ· Q2 2026
TUDOR INVESTMENT CORP ET ALReduced
Hedge Fund
$235K· 0.1% of total· 0.0% port· 3K sh· $-508K QoQ· Q2 2026
Fulcrum Asset Management LLPAdded
Hedge Fund
$191K· 0.0% of total· 0.0% port· 2K sh· — QoQ· Q2 2026
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